4 thoughts on “a paediatric pathology case”

  1. I think there are two possibilities. firstly these may be atypical stem cells in the endocardium with cell-rest realities. if so, unlikely to be of relevance. we have little knowledge of this site in such young children, but the mesothelial/endodermal interface is intriguing in the heart often.
    secondly, these may be polynucleate cells with a viral ‘flavour’. electron microscopy would be of interest, but serology for standard cardiomyopathic virus might also be worthwhile.

  2. There are two separate thing here. The first are clusters of cells resembling multinucleate cells. These are seen in the endocardium of the interatrial septum of normal hearts, most frequently in the region of the oval fossa and stain for endothelial markers and have been called Pritchard structures. They are said to be uncommon in children, but I think this is untrue.
    The second are nuclei with the appearance of Anitschkow cells. These are frequently seen in fetal and neonatal hearts and are confined to the heart (and larynx) and can be in any cell type. They have no known pathological significance. (Favara BE, Moores H. Anitschkow nuclear structure: a study of pediatric hearts. Pediatr Pathol 1987; 7: 151-164)

    1. Thank you Dr Ashworth. I am glad to have something to read around regarding these structures and cells. It is not the first time I that have seen these Anitschkow-like cells and I am relieved to see that they are recognised by others. I was fearful of overinterpreting their features; particularly the caterpillar appearing nuclei. I can also say that it is not the first time that I have seen the so-called Pritchard structures either. I value now knowing that I can relax when I see them again.

  3. An addition to my comment above. A reference for Prichard Structures:
    Acebo E, Val-Bernal JF, Gomex -Roman JJ. Prichard’s structures of the fossa ovalis are not histogenetically related to cardiac myxoma. Histopathology 2001; 39: 529-535

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